DRAVP ID  DRAVPa1241

Peptide Name   Sequence 12 from Patent US 5859187 A

Sequence  APGDEPAPP

Sequence Length  9

Source  Synthetic construct

Target Organism  HSV

Patent Type  Granted Patent

Publication Date  1999-01-12

Patent No  US 5859187 A

Family Info  IT 9019881 D0, GB 9007137 D0, CA 2011884 A1, DE 4010593 A1, FR 2645157 A1, GB 2230011 A, JP H0341094 A, IT 9019881 A1, US 5120639 A, GB 2230011 B, IT 1241092 B, FR 2645157 B1, US 5859187 A

Patent Title  Antiviral peptides

Comment  The peptide inhibits HSV by UL42 of HSV DNA polymerase(IC50=115 μM).

Abstract  Inhibition of UL42 stimulation of herpesvirus DNA polymerase activity is exhibited by novel compounds of the formulas EQU W'--A.sub.1 --A.sub.2 --A.sub.3 --A.sub.4 --A.sub.5 --A.sub.6 --A.sub.7 --A.sub.8 --A.sub.9 --A.sub.10 --A.sub.11 --X ?SEQ. ID NO: 1! and EQU Y'--A.sub.12 --A.sub.13 --A.sub.14 --A.sub.15 --A.sub.16 --A.sub.17 --Z ?SEQ. ID NO: 2! that are useful as antiviral agents.