DRAVP ID  DRAVPa1407

Peptide Name   Sequence 18 from Patent US 20040091855

Sequence  TLTVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGI

Sequence Length  38

Source  Synthetic construct

Target Organism  HIV

Patent Type  Patent Application

Publication Date  2004-05-13

Patent No  US 2004/0091855 A1

Family Info  US 2004/0091855 A1

Patent Title  Method for production of antivirals by use of HIV-derived HR1 peptides, and trimers formed therefrom

Comment  No comments found in patent

Abstract  Provided is a method for identifying or producing a molecule having antiviral activity against HIV. More particularly, provided is a method for identifying or producing a molecule that can inhibit the binding between HR1 and HR2 regions of HIV gp41, wherein complex formation is observed in vitro between a trimer with HR2 peptide in the presence of the molecule, and detected in vitro is the ability of the molecule to inhibit complex formation as an indicator of the antiviral activity of the molecule. The trimer is comprised of synthetic peptide comprising an amino acid sequence derived from the HR1 region of HIV-1 gp41 and further comprising one or more amino acid substitutions in a hydrophobic domain of the HR1 region of HIV which enable the synthetic peptide to self-assemble in solution into trimers.