DRAVP ID  DRAVPa1441

Peptide Name   Sequence 5 from Patent US 20050130884

Sequence  KLALKLALKALKAALKLA

Sequence Length  18

Source  Synthetic construct

Target Organism  HSV

Patent Type  Patent Application

Publication Date  2005-06-16

Patent No  US 2005/0130884 A1

Family Info  WO 2001/057072 A2, CA 2399676 A1, AU 2001/036700 A, WO 2001/057072 A3, EP 1272510 A2, JP 2003522185 A, US 2005/0130884 A1, AU 784264 B2, EP 1272510 B1, AT 374208 T, DE 60130641 D1, ES 2293977 T3, US 7

Patent Title  Pharmacologically active antiviral peptides and methods of their use

Comment  The peptide shows antiviral activity against a wide range of enveloped and non-enveloped viruses. Examples of such enveloped viruses include, but are not limited to, human immunodeficiency virus (HIV), vesiculovirus (VSV), herpes simplex viruses (HSV-1 and HSV-2), and other herpes viruses, for example, varicella-zoster virus (VZV), EBV, equine herpes virus (EHV), and human cytomegalovirus (HCMV). Examples of non-enveloped viruses include, but are not limited to, human papilloma virus (HPV) and adenoviruses.The peptide shows antiviral activity against HSV by blocking virus entry(IC50=11 μM).

Abstract  This invention relates to peptides having antiviral properties. The antiviral peptides comprise membrane transiting peptides, and active fragments and derivatives of such peptides. The antiviral peptides exhibit activity against a broad spectrum of viruses, including enveloped and nonenveloped viruses, and are used in pharmaceutical compositions to prevent and/or treat viral infections.