DRAVP ID DRAVPa1448
Peptide Name Sequence 13 from Patent US 20050130884
Sequence DPKGDPKGVTVTVTVTVTGKGDPKPD
Sequence Length 26
Source Synthetic construct
Target Organism HSV
Patent Type Patent Application
Publication Date 2005-06-16
Patent No US 2005/0130884 A1
Family Info WO 2001/057072 A2, CA 2399676 A1, AU 2001/036700 A, WO 2001/057072 A3, EP 1272510 A2, JP 2003522185 A, US 2005/0130884 A1, AU 784264 B2, EP 1272510 B1, AT 374208 T, DE 60130641 D1, ES 2293977 T3, US 7
Patent Title Pharmacologically active antiviral peptides and methods of their use
Comment The peptide shows antiviral activity against a wide range of enveloped and non-enveloped viruses. Examples of such enveloped viruses include, but are not limited to, human immunodeficiency virus (HIV), vesiculovirus (VSV), herpes simplex viruses (HSV-1 and HSV-2), and other herpes viruses, for example, varicella-zoster virus (VZV), EBV, equine herpes virus (EHV), and human cytomegalovirus (HCMV). Examples of non-enveloped viruses include, but are not limited to, human papilloma virus (HPV) and adenoviruses.
Abstract This invention relates to peptides having antiviral properties. The antiviral peptides comprise membrane transiting peptides, and active fragments and derivatives of such peptides. The antiviral peptides exhibit activity against a broad spectrum of viruses, including enveloped and nonenveloped viruses, and are used in pharmaceutical compositions to prevent and/or treat viral infections.