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DRAVP ID DRAVPa1687
Peptide Name Sequence 17 from Patent US 20090281041
Sequence IAQAKVEXWMTXTLLVAN
Sequence Length 18
Source Synthetic construct
Target Organism HIV
Patent Type Patent Application
Publication Date 2009-11-12
Patent No US 2009/0281041 A1
Family Info CA 2725227 A1, WO 2009/137532 A1, AU 2009/244400 A1, US 2009/0281041 A1, AU 2009/244400 A2, EP 2283033 A1, JP 2011522796 A, US 8324153 B2, AU 2009/244400 B2, US 2013/0059776 A1, US 8933019 B2
Patent Title Antiviral Cell-Penetrating Peptides
Comment The peptide shows antiviral activity against HIV-1 IIIB(IC50=7.2 ± 1.2 μM) and exhibits cytotoxicity against MT-2 cells(CC50>124.4 μM).The 'X' at position 8 and 12 indicates (S)-a-2-(2'-pentenyl)alanine, X(8) and X(12) are cross-linked by hydrocarbon stapling.
Abstract Disclosed herein are cell penetrating peptides useful as treatment for Human Immunodeficiency Virus.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.