Patent Information


DRAVP ID  DRAVPa1687

Peptide Name   Sequence 17 from Patent US 20090281041

Sequence  IAQAKVEXWMTXTLLVAN

Sequence Length  18

Source  Synthetic construct

Target Organism  HIV

Patent Type  Patent Application

Publication Date  2009-11-12

Patent No  US 2009/0281041 A1

Family Info  CA 2725227 A1, WO 2009/137532 A1, AU 2009/244400 A1, US 2009/0281041 A1, AU 2009/244400 A2, EP 2283033 A1, JP 2011522796 A, US 8324153 B2, AU 2009/244400 B2, US 2013/0059776 A1, US 8933019 B2

Patent Title  Antiviral Cell-Penetrating Peptides

Comment  The peptide shows antiviral activity against HIV-1 IIIB(IC50=7.2 ± 1.2 μM) and exhibits cytotoxicity against MT-2 cells(CC50>124.4 μM).The 'X' at position 8 and 12 indicates (S)-a-2-(2'-pentenyl)alanine, X(8) and X(12) are cross-linked by hydrocarbon stapling.

Abstract  Disclosed herein are cell penetrating peptides useful as treatment for Human Immunodeficiency Virus.