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DRAVP ID DRAVPa1754
Peptide Name Sequence 2 from Patent US20090233868 A1
Sequence KYKETDL
Sequence Length 7
Source Human La protein
Target Organism HCV
Patent Type Patent Application
Publication Date 2009-09-17
Patent No US20090233868 A1
Family Info WO/2006/117805，IN520/CHE/2005，EP1877431，US20110091966，CA2606668
Patent Title Small antiviral peptides against hepatitis C virus
Comment
Abstract Disclosed herein is a small 7 amino-acid peptide, corresponding to the C terminus of RRM2 of the human La protein that binds to the IRES element of hepatitis C virus RNA and its derivatives. This disclosure demonstrates that this 7-mer interacts with the HCV IRES element both in vitro and in vivo and can compete against cellular La protein in binding to the HCV RNA. It is also shown here that this 7-mer peptide is able to inhibit HCV-IRES mediated translation in vivo which, in turn, leads to decreased viral replication.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.