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DRAVP ID DRAVPa2309
Peptide Name Sequence 1 from Patent US20210040153A1
Sequence KHGHHRH
Sequence Length 7
Source Synthetic peptide
Target Organism DENV
Patent Type Patent Application
Publication Date 2021-02-11
Patent No US20210040153A1
Family Info CN108395470, WO/2019/137247
Patent Title OLIGOPEPTIDE HAVING DENGUE VIRUS REPLICATION INHIBITION FUNCTION AND APPLICATION THEREOF
Comment
Abstract The present invention relates to the field of virology, and specifically discloses a short peptide having a dengue virus replication inhibition function and an application thereof. The amino acid sequence of the short peptide provided in the present invention is KHGHHRH, i.e. Lys-His-Gly-His-His-Arg-His (SEQ ID NO. 1). The short peptide has a high specificity affinity with NS5 and has the function of efficiently inhibiting dengue virus replication, the anti-viral effect thereof not been limited to DENV-2, but also having a significant inhibitory effect on the replication of type 1, type 3, and type 4 dengue virus. One cysteine is added to the two ends of the short peptide sequence, the short peptide being cyclised by means of the cysteines at the two ends to form a cyclic peptide. The obtained cyclic peptide strengthens the dengue virus replication inhibition function, and can be used for specific treatment of dengue virus infection.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.