DRAVP ID  DRAVPa2356

Peptide Name   Sequence 2 from CN119020340A

Sequence  YGRKKRRQRRRESLVNEYDDN

Sequence Length  21

Source  human

Target Organism  RV

Patent Type  Patent Application

Publication Date  2024-11-26

Patent No  CN119020340A

Family Info  CN 119020340 A

Patent Title  Polypeptide and application thereof in preparation of anti-rabies virus medicine

Comment 

Abstract  The invention discloses a polypeptide and application thereof in preparation of anti-rabies virus drugs, and belongs to the technical field of biological medicines. The amino acid sequence of the polypeptide is as shown in SEQ ID NO.1, the polypeptide is derived from 190-199 amino acids of human PDIA3 protein, the polypeptide can be fused with a cell penetrating peptide to form a polypeptide with an amino acid sequence as shown in SEQ ID NO.2, and the problems that the polypeptide is easy to degrade and difficult to enter cells are solved. The polypeptide can be combined with surface glycoprotein of the rabies virus to resist infection of the rabies virus, and can be used for preparing anti-rabies virus drugs. The polypeptide disclosed by the invention has the advantages of simple and feasible preparation method, good biocompatibility, small side effect, safety, high efficiency and the like, and can be produced on a large scale in a short time. The invention lays a foundation for designing safe and effective polypeptide for treating rabies, and has good development and application prospects.