DRAVP ID  DRAVPa2357

Peptide Name   Sequence 2 from CN118994306A

Sequence  LVIARQKVR

Sequence Length  9

Source  Synthetic construct

Target Organism  Hantaan virus, Chikungunya virus

Patent Type  Patent Application

Publication Date  2024-11-22

Patent No  CN118994306A

Family Info  CN 118994306 A

Patent Title  Advanced epitope peptide of hantavirus nucleocapsid protein and application of dominant epitope peptide in preparation of anti-hantavirus vaccine

Comment 

Abstract  The invention belongs to the technical field of microbial immunity, and particularly relates to dominant epitope peptide of hantavirus nucleocapsid protein and application of the dominant epitope peptide in preparation of an anti-hantavirus vaccine. The amino acid sequence of the dominant epitope peptide is one of SEQ ID NO.1-9, the common amino acid fragment of the dominant epitope peptide is an MHC-II type antigenic nonapeptide, and the nonapeptide sequence is shown as SEQ ID NO.10-12. The invention further discloses a preparation method of the MHC-II type antigenic nonapeptide. According to the present invention, the binding capacity and the immune response effect of the dominant epitope peptides and MHC II molecules are verified through the ELISpot test, and the immunological characteristics of the dominant epitope peptides are determined by the nonapeptide core, such that the immunobiology of the HTNV NP can be easily understood, and the epitope vaccine design for the HTNV NP can be perfected in the future.