DRAVP ID  DRAVPa2454

Peptide Name   Sequence 30 from Patent CN118027159A

Sequence  YAFGNCPKYIGVKSLKLAVG

Sequence Length  20

Source  Synthetic construct

Target Organism  AIV

Patent Type  Patent Application

Publication Date  2024-05-14

Patent No  CN118027159A

Family Info  CN 118027159 A

Patent Title  Broad-spectrum B cell epitope peptide of HA1 protein of H9 subtype avian influenza virus and application of broad-spectrum B cell epitope peptide

Comment 

Abstract  The invention belongs to the technical field of biology, and particularly relates to an H9 subtype avian influenza virus HA1 protein broad-spectrum B cell epitope peptide and application thereof, two sections of H9 subtype AIV HA1-derived B cell epitopes of an aa 39-59 polypeptide (ENNVPVTHAKELLHTEHNGM) and an aa 309-329 polypeptide (YAFGNCPKYIGVKSLKLAVG) are screened and identified, the B cell epitopes have high conservative property, besides the 320 < th > amino acid of the aa 309-329 polypeptide, the B cell epitopes of the aa 39-59 polypeptide and the YAFGNCPKYIGVKSLKLAVG are added into the B cell epitopes of the aa 309-329 polypeptide, and The conservative rates of other sites of the two polypeptides in the H9 AIV subtype are both greater than 96%. Serological experiments find that the two polypeptides can be specifically combined with different branch strains in the H9 AIV subtype and do not react with other subtype avian influenza viruses; meanwhile, the aa 309-329 polypeptide immune serum can also be specifically combined with different branched strains.