DRAVP ID  DRAVPa2471

Peptide Name   Sequence 2 from Patent CN117659141A

Sequence  SVLHSTQDLFLPFFS

Sequence Length  15

Source  Synthetic construct

Target Organism  SARS-CoV-2

Patent Type  Patent Application

Publication Date  2024-03-08

Patent No  CN117659141A

Family Info  CN 117659141 A

Patent Title  Novel specific T cell epitope peptide for screening coronavirus S1, N and M protein holoproteome and application thereof

Comment 

Abstract  The invention discloses a specific T cell epitope peptide for screening a whole proteome of S1, N and M proteins of a novel coronavirus and application, relates to the technical field of biological medicines, and has the technical key points that the scheme of the invention provides a plurality of novel coronavirus CD4 + T and CD8 + T cell epitope polypeptides, the invention also relates to a gene for coding the epitope polypeptide, a recombinant protein or a compound containing the epitope polypeptide, a sensitization antigen presenting cell and a specific immune effector cell aiming at the epitope polypeptide in research and development of novel coronavirus vaccines and disease treatment. The polypeptide is screened on the basis of a peripheral blood sample of a convalescent patient infected with Omicro BA.5 after enhanced inoculation of an inactivated vaccine, CD4 + T and CD8 + T cellular immune response aiming at novel coronavirus protein can be safely and effectively induced, and the polypeptide has important guiding significance on research and development of novel vaccines of novel coronavirus.