To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
DRAVP ID DRAVPa2573
Peptide Name SEQ ID NO:64
Sequence VGNWAKVLVVLLLFAGVD
Sequence Length 18
Source HCV envelope glycoprotein (E1, E2)
Target Organism HCV
Patent Type Granted Patent
Publication Date 2008-08-26
Patent No US7416733
Family Info DK1558276T3, WO2004044220A2, JP2010167496A, EP20100181693
Patent Title Flavivirus fusion inhibitors
Comment
Abstract The present invention relates to peptides and methods of inhibiting fusion between the virion envelope of Flaviviruses and membranes of the target cell, the process that delivers the viral genome into the cell cytoplasm. The invention provides for methods which employ peptides or peptide derivatives to inhibit Flavivirus:cell fusion. The present invention is based in part on the discovery that E1 envelope glycoprotein of hepaciviruses and E6 envelope glycoprotein of pestivirus have previously undescribed structures, truncated class II fusion proteins. The present invention provides peptides and methods of treatment and prophylaxis of diseases induced by Flaviviruses.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.