DRAVPR ID  DRAVPR0015

Name   2'-5'-oligoadenylate synthase 1(p42 OAS)

Sequence  MELRHTPARDLDKFIEDHLLPNTCFRTQVKEAIDIVCRFLKERCFQGTADPVRVSKVVKGGSSGKGTTLRGRSDADLVVFLTKLTSFEDQLRRRGEFIQEIRRQLEACQREQKFKVTFEVQSPRRENPRALSFVLSSPQLQQEVEFDVLPAFDALGQWTPGYKPNPEIYVQLIKECKSRGKEGEFSTCFTELQRDFLRNRPTKLKSLIRLVKHWYQTCKKTHGNKLPPQYALELLTVYAWEQGSRKTDFSTAQGFQTVLELVLKHQKLCIFWEAYYDFTNPVVGRCMLQQLKKPRPVILDPADPTGNVGGGDTHSWQRLAQEARVWLGYPCCKNLDGSLVGAWTMLQKI

Sequence Length  349

Source  Sus scrofa (Pig)

UniProt ID Q29599

Gene OAS1

Target Organism  VSV,HSV-2,EMCV

Activity 

• [Ref.20844035]encephalomyocarditis virus (EMCV):inhibition of the cytopathic effect in HepG2 cells(EC50=24.5 μg/ml);inhibition of the cytopathic effect in Vero cells(EC50=18.5 μg/ml).

PDB ID  1PX5  4RWN  4RWO  4RWP  4RWQ 

Predicted Structure Download  AF-Q29599-F1

Modification  No modifications on the sequence.

The OAS family of proteins mediates antiviral activity via the synthesis of 2-5A and subsequent activation of RNase L.

Literature 1

Title   Extracellular 2'-5' oligoadenylate synthetase stimulates RNase L-independent antiviral activity: a novel mechanism of virus-induced innate immunity.

Pubmed ID   20844035

Author   Kristiansen H, Scherer CA, McVean M, Iadonato SP, Vends S, Thavachelvam K, Steffensen TB, Horan KA, Kuri T, Weber F, Paludan SR, Hartmann R.