General Information


DRAVPR ID  DRAVPR0016

Name   Trem-like transcript 4 protein(TLT-4)

Sequence 

Sequence Length  263

Source  Mus musculus (Mouse)

UniProt ID Q3LRV9

Gene Treml4



Activity Information


Target Organism  IAV

Activity  [Ref.25848864]TREML4 plays an important role in the regulation of TLR7 signaling and that its expression in vivo is required for antiviral host defense to influenza and for promotion of TLR7-mediated autoimmune disease.



Structure Information


PDB ID  None

Predicted Structure Download  AF-Q3LRV9-F1

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Modification  ①Glycosylation of Asn at position 100.②There is a disulfide bond between Cys47 and Cys116.



Comment


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Literature Information


Literature 1

Title   The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity.

Pubmed ID   25848864

Author   Ramirez-Ortiz ZG, Prasad A, Griffith JW, Pendergraft WF 3rd, Cowley GS, Root DE, Tai M, Luster AD, El Khoury J, Hacohen N, Means TK.