DRAVPR ID  DRAVPR0018

Name   Antiviral protein I

Sequence  MKSMLVVTISIWLILAPTSTWAVNTIIYNVGSTTISKYATFLNDLRNEAKDPSLKCYGIPMLPNTNTNPKYVLVELQGSNKKTITLMLRRNNLYVMGYSDPFETNKCRYHIFNDISGTERQDVETTLCPNANSRVSKNINFDSRYPTLESKAGVKSRSQVQLGIQILDSNIGKISGVMSFTEKTEAEFLLVAIQMVSEAARFKYIENQVKTNFNRAFNPNPKVLNLQETWGKISTAIHDAKNGVLPKPLELVDASGAKWIVLRVDEIKPDVALLNYVGGSCQTTYNQNAMFPQLIMSTYYNYMVNLGDLFEGF

Sequence Length  313

Source  Phytolacca americana (American pokeweed) (Phytolacca decandra)

UniProt ID P10297

Gene PAP1

Target Organism  No specific virus mentioned in the entry

Activity 

• [Ref.10403789]Human immunodeficiency virus (HIV)-1:inhibition the replication of HIV-1 in human peripheral blood mononuclear cells(IC50=17 nM);
• tobacco mosaic virus(TMV):PAP-I cause concentration-dependent depurination of genomic RNA purified from TMV.

PDB ID  1D6A  1PAF  1PAG  1QCG  1QCI  1QCJ 

Predicted Structure Download  AF-P10297-F1

Modification  There are two disulfide bonds between Cys56 and Cys281, Cys107 and Cys128.

The potent antiviral activity of PAP may in part be due to its unique ability to extensively depurinate viral RNA.

Literature 1

Title   Pokeweed antiviral protein isoforms PAP-I, PAP-II, and PAP-III depurinate RNA of human immunodeficiency virus (HIV)-1.

Pubmed ID   10403789

Author   Rajamohan F, Venkatachalam TK, Irvin JD, Uckun FM.