General Information


DRAVPR ID  DRAVPR0020

Name   Inactive 2'-5'-oligoadenylate synthase 1B

Sequence 

Sequence Length  376

Source  Mus musculus (Mouse)

UniProt ID Q60856

Gene Oas1b



Activity Information


Target Organism  WNV

Activity 

  • [Ref.16371364]West Nile virus(WNV):Oas1b inhibits the replication of WNV by preventing viral RNA accumulation inside infected cells.



Structure Information


PDB ID  None

Predicted Structure Download  AF-Q60856-F1

';

Modification  No modifications on the sequence.



Comment


Oas1b-dependent antiviral activity is restricted to the early stages of WNV replication,the Oas1b-mediated inhibition of viral protein synthesis and the subsequent suppression of viral growth are due to a lack of accumulation of viral RNA inside cells.



Literature Information


Literature 1

Title   The 2',5'-oligoadenylate synthetase 1b is a potent inhibitor of West Nile virus replication inside infected cells.

Pubmed ID   16371364

Author   Kajaste-Rudnitski A, Mashimo T, Frenkiel MP, Guénet JL, Lucas M, Desprès P.