DRAVPR ID  DRAVPR0026

Name   Concanavalin-A

Sequence  MAISKKSSLFLPIFTFITMFLMVVNKVSSSTHETNALHFMFNQFSKDQKDLILQGDATTGTDGNLELTRVSSNGSPQGSSVGRALFYAPVHIWESSAVVASFDATFTFLIKSPDSHPADGIAFFISNIDSSIPSGSTGRLLGLFPDANVIRNSTTIDFNAAYNADTIVAVELDTYPNTDIGDPNYPHIGIDIKSVRSKKTAKWNMQNGKVGTAHIIYNSVGKRLSAVVSYPNGDSATVSYDVDLDNVLPEWVRVGLSASTGLYKETNTILSWSFTSKLKSNEIPDIATVV

Sequence Length  290

Source  Canavalia gladiata (Sword bean) (Dolichos gladiatus)

UniProt ID P14894

Gene N/A

Target Organism  HIV-1

Activity 

• [Ref.15935326]Human immunodeficiency virus type-1(HIV-1):Inhibits HIV-1 reverse transcriptase.(IC50=35 μM)

PDB ID  1WUV  2D7F  2EF6  2OVU  2P2K 

Predicted Structure Download  AF-P14894-F1

Modification  Glycosylation of Asn at position 152.

The mechanism of anti-HIV-1 activity may be protein–protein interaction.

Literature 1

Title   Isolation and characterization of a glucose/mannose/rhamnose-specific lectin from the knife bean Canavalia gladiata.

Pubmed ID   15935326

Author   Wong JH, Ng TB.