DRAVPR ID  DRAVPR0028

Name   DNA dC->dU-editing enzyme APOBEC-3B

Sequence  MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVYFKPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVTIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAFLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEVERLDNGTWVLMDQHMGFLCNEAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFVYRQGCPFQPWDGLEEHSQALSGRLRAILQNQGN

Sequence Length  382

Source  Homo sapiens (Human)

UniProt ID Q9UH17

Gene APOBEC3B

Target Organism  HTLV-1,SIV

Activity 

• [Ref.22457529]Human T-lymphotropic virus type 1(HTLV-1):APOBEC3B hapII potently decrease HTLV-1 infectivity.
• [Ref.15466872]simian immunodeficiency virus(SIV):APOBEC3B induced abundant G → A mutations in both wild-type and SIV reverse transcripts, exert efficient antiretroviral effects in infected target cells.

PDB ID  2NBQ  5CQD  5CQH  5CQI  5CQK  5SXG  5SXH  5TD5  5TKM  6NFK  6NFL  6NFM 

Predicted Structure Download  AF-Q9UH17-F1

Modification  No modifications on the sequence.

Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1).

Literature 1

Title   APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1.

Pubmed ID   22457529

Author   Ooms M, Krikoni A, Kress AK, Simon V, Münk C.

Literature 2

Title   APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication.

Pubmed ID   15466872

Author   Yu Q, Chen D, König R, Mariani R, Unutmaz D, Landau NR.