DRAVPR ID  DRAVPR0029

Name   DNA dC->dU-editing enzyme APOBEC-3C

Sequence  MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEGIKRRSVVSWKTGVFRNQVDSETHCHAERCFLSWFCDDILSPNTKYQVTWYTSWSPCPDCAGEVAEFLARHSNVNLTIFTARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWENFVYNDNEPFKPWKGLKTNFRLLKRRLRESLQ

Sequence Length  190

Source  Homo sapiens (Human)

UniProt ID Q9NRW3

Gene APOBEC3C

Target Organism  SIV,HSV-1,EBV

Activity 

• [Ref.15466872]simian immunodeficiency virus(SIV):APOBEC3C have potent antiviral activity against simian immuno-deficiency virus (SIV).
• [Ref.21632763]Herpes simplex virus 1(HSV-1):APOBEC3C restricts the replication of HSV-1;
• Epstein-Barr virus (EBV):APOBEC3C restricts the replication of EBV.

PDB ID  3VM8  3VOW 

Predicted Structure Download  AF-Q9NRW3-F1

Modification  No modifications on the sequence.

Exhibits antiviral activity against simian immunodeficiency virus (SIV), herpes simplex virus 1 (HSV-1) and Epstein-Barr virus (EBV).

Literature 1

Title   APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication.

Pubmed ID   15466872

Author   Yu Q, Chen D, König R, Mariani R, Unutmaz D, Landau NR.

Literature 2

Title   Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo.

Pubmed ID   21632763

Author   Suspène R, Aynaud MM, Koch S, Pasdeloup D, Labetoulle M, Gaertner B, Vartanian JP, Meyerhans A, Wain-Hobson S.