DRAVPR ID  DRAVPR0030

Name   DNA dC->dU-editing enzyme APOBEC-3D

Sequence  MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVLPKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFLAEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEDFAYCWENFVCNEGQPFMPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESWLCFTMEVTKHHSAVFRKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFVSCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREILQ

Sequence Length  386

Source  Homo sapiens (Human)

UniProt ID Q96AK3

Gene APOBEC3D

Target Organism  HIV-1

Activity 

• [Ref.16920826]Human immunodeficiency virus type 1 (HIV-1):after the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA

PDB ID  None

Predicted Structure Download  AF-Q96AK3-F1

Modification  No modifications on the sequence.

APOBEC3D blocked the replication of both HIV-1 and SIV but not that of MLV.

Literature 1

Title   Identification of APOBEC3DE as another antiretroviral factor from the human APOBEC family.

Pubmed ID   16920826

Author   Dang Y, Wang X, Esselman WJ, Zheng YH.