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General Information
DRAVPR ID DRAVPR0032
Name DNA dC->dU-editing enzyme APOBEC-3G
Sequence
Sequence Length 384
Source Homo sapiens (Human)
UniProt ID Q9HC16
Gene APOBEC3G
Activity Information
Target Organism HIV-1,HBV
Activity
Structure Information
PDB ID 2JYW 2KBO 2KEM 3E1U 3IQS 3IR2 3V4J 3V4K 4ROV 4ROW 5ZVA 5ZVB 6BUX 6BWY 6K3J 6K3K
Predicted Structure Download AF-Q9HC16-F1
Modification Phosphorylation of Thr at position 32,218
Comment
Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV).
Literature Information
Literature 1
Title Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts.
Pubmed ID 12808466
Author Mangeat B, Turelli P, Caron G, Friedli M, Perrin L, Trono D.
Literature 2
Title Inhibition of hepatitis B virus replication by APOBEC3G.
Pubmed ID 15031497
Author Turelli P, Mangeat B, Jost S, Vianin S, Trono D.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.