DRAVPR ID  DRAVPR0034

Name   DNA dC->dU-editing enzyme APOBEC-3G

Sequence  MNPQIRNMVEQMEPDIFVYYFNNRPILSGRNTVWLCYEVKTKDPSGPPLDANIFQGKLYPEAKDHPEMKFLHWFRKWRQLHRDQEYEVTWYVSWSPCTRCANSVATFLAEDPKVTLTIFVARLYYFWKPDYQQALRILCQERGGPHATMKIMNYNEFQHCWNEFVDGQGKPFKPRKNLPKHYTLLHATLGELLRHVMDPGTFTSNFNNKPWVSGQRETYLCYKVERSHNDTWVLLNQHRGFLRNQAPDRHGFPKGRHAELCFLDLIPFWKLDDQQYRVTCFTSWSPCFSCAQKMAKFISNNKHVSLCIFAARIYDDQGRCQEGLRTLHRDGAKIAVMNYSEFEYCWDTFVDRQGRPFQPWDGLDEHSQALSGRLRAI

Sequence Length  377

Source  Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

UniProt ID Q7YR25

Gene APOBEC3G

Target Organism  HIV-1,SFV

Activity 

• [Ref.12859895]Human immunodeficiency virus type 1(HIV-1):APOBEC3G can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells.
• [Ref.16378963]simian foamy virus (SFV):inhibition of the replication of SFV.

PDB ID  None

Predicted Structure Download  No predicted structure information available for the entry

Modification  Phosphorylation of Thr at position 32,218.

Exhibits antiviral activity against vif-deficient: HIV-1 and simian immunodeficiency viruses (SIVs) and also against simian foamy virus (SFV).

Literature 1

Title   Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif.

Pubmed ID   12859895

Author   Mariani R, Chen D, Schröfelbauer B, Navarro F, König R, Bollman B, Münk C, Nymark-McMahon H, Landau NR.

Literature 2

Title   Restriction of foamy viruses by APOBEC cytidine deaminases.

Pubmed ID   16378963

Author   Delebecque F, Suspène R, Calattini S, Casartelli N, Saïb A, Froment A, Wain-Hobson S, Gessain A, Vartanian JP, Schwartz O.