DRAVPR ID  DRAVPR0037

Name   DNA dC->dU-editing enzyme APOBEC-3H

Sequence  MALLTAKTFSLQFNNKRRVNKPYYPRKALLCYQLTPQNGSTPTRGHLKNKKKDHAEIRFINKIKSMGLDETQCYQVTCYLTWSPCPSCAGELVDFIKAHRHLNLRIFASRLYYHWRPNYQEGLLLLCGSQVPVEVMGLPEFTDCWENFVDHKEPPSFNPSEKLEELDKNSQAIKRRLERIKSRSVDVLENGLRSLQLGPVTPSSSIRNSR

Sequence Length  210

Source  Macaca mulatta (Rhesus macaque)

UniProt ID Q19Q52

Gene APOBEC3H

Target Organism  HIV-1

Activity 

• [Ref.21835787]Human immunodeficiency virus type 1 (HIV-1):the protein expressed in CD4 T lymphocytes, are packaged into and restrict Vif-deficient HIV-1 when stably expressed in T cells, mutate proviral DNA.

PDB ID  None

Predicted Structure Download  AF-Q19Q52-F1

Modification  No modifications on the sequence.

Exhibits antiviral activity against vif-deficient: HIV-1 and simian immunodeficiency viruses (SIV).

Literature 1

Title   Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1.

Pubmed ID   21835787

Author   Hultquist JF, Lengyel JA, Refsland EW, LaRue RS, Lackey L, Brown WL, Harris RS.