DRAVPR ID  DRAVPR0039

Name   E3 ubiquitin-protein ligase TRIM52

Sequence  MAGYATTPSPMQTLQEEAVCAICLDYFKDPVSISCGHNFCRGCVTQLWSKEDEEDQNEEEDEWEEEEDEEAVGAMDGWDGSIREVLYRGNADEELFQDQDDDELWLGDSGITNWDNVDYMWDEEEEEEEEDQDYYLGGLRPDLRIDVYREEEILEAYDEDEDEELYPDIHPPPSLPLPGQFTCPQCRKSFTRRSFRPNLQLANMVQIIRQMCPTPYRGNRSNDQGMCFKHQEALKLFCEVDKEAICVVCRESRSHKQHSVLPLEEVVQEYQEIKLETTLVGILQIEQESIHSKAYNQ

Sequence Length  297

Source  Homo sapiens (Human)

UniProt ID Q96A61

Gene TRIM52

Target Organism  JEV

Activity 

• [Ref.27667714]Japanese encephalitis virus (JEV):TRIM52 interacted with NS2A and induced NS2A ubiquitination, resulting in NS2A degradation.

PDB ID  None

Predicted Structure Download  AF-Q96A61-F1

Modification  No modifications on the sequence.

Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV) and West Nile virus (WNV).

Literature 1

Title   TRIM52 inhibits Japanese Encephalitis Virus replication by degrading the viral NS2A.

Pubmed ID   27667714

Author   Fan W, Wu M, Qian S, Zhou Y, Chen H, Li X, Qian P.