DRAVPR ID  DRAVPR0042

Name   Interferon-induced transmembrane protein 3

Sequence  MNHTSQAFITAASGGQPPNYERIKEEYEVAEMGAPHGSASVRTTVINMPREVSVPDHVVWSLFNTLFMNFCCLGFIAYAYSVKSRDRKMVGDVTGAQAYASTAKCLNISTLVLSILMVVITIVSVIIIVLNAQNLHT

Sequence Length  137

Source  Mus musculus (Mouse)

UniProt ID Q9CQW9

Gene Ifitm3

Target Organism  SARS-CoV,IAV,EBOV,SARS-CoV-2

Activity 

• [Ref.21253575]influenza A virus(IAV):Ifitm3 inhibits infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein.
• SARS-CoV:IFITM proteins can restrict the replication of infectious SARS coronavirus (SARS-CoV) and entry mediated by the SARS-CoV spike (S) protein.
• Ebola virus(EBOV):IFITM proteins restricted infection mediated by the entry glycoproteins (GP1,2) of Ebola filoviruses.
• [Ref.33270927]SARS-CoV-2:IFITM3 likely restrict SARS‐CoV‐2 infection by mechanically disfavoring viral membrane fusion reactions occurring at endosomes.

PDB ID  None

Predicted Structure Download  AF-Q9CQW9-F1

Modification  ①Phosphorylation of Ser at position 20,27.②The Cys at position 71,72,105 indicates S-palmitoyl cysteine.

VAMP8 plays an antiviral role in response to Japanese encephalitis virus (JEV).

Literature 1

Title   Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus.

Pubmed ID   21253575

Author   Huang IC, Bailey CC, Weyer JL, Radoshitzky SR, Becker MM, Chiang JJ, Brass AL, Ahmed AA, Chi X, Dong L, Longobardi LE, Boltz D, Kuhn JH, Elledge SJ, Bavari S, Denison MR, Choe H, Farzan M.

Literature 2

Title   Opposing activities of IFITM proteins in SARS-CoV-2 infection.

Pubmed ID   33270927

Author   Shi G, Kenney AD, Kudryashova E, Zani A, Zhang L, Lai KK, Hall-Stoodley L, Robinson RT, Kudryashov DS, Compton AA, Yount JS.