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General Information
DRAVPR ID DRAVPR0051
Name Cyanovirin-N
Sequence
Sequence Length 101
Source Nostoc ellipsosporum
UniProt ID P81180
Gene N/A
Activity Information
Target Organism HIV
Activity
Structure Information
PDB ID 1LOM 2RDK 3CZZ 4J4C 6X7H
Predicted Structure Download AF-P81180-F1
Modification There are two disulfide bonds between Cys8 and Cys22, Cys58 and Cys73.
Comment
Elevated cellular levels of human BST-2 inhibited the release of virus-like particles (VLPs) consisting of the matrix proteins of multiple highly virulent NIAID Priority Pathogens, including arenaviruses (LASV and Machupo virus [MACV]), filoviruses (ZEBOV and MARV), and paramyxoviruses (Nipah virus). However, filoviruses, RVFV, and CPXV are immune to the inhibitory effect of BST-2.
Literature Information
Literature 1
Title The antiviral protein cyanovirin-N: the current state of its production and applications.
Pubmed ID 20162270
Author Xiong S, Fan J, Kitazato K.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.