DRAVPR ID  DRAVPR0053

Name   Interleukin enhancer-binding factor 2

Sequence  MRGDRGRGRGGRFGSRGGPGGGFRPFVPHIPFDFYLCEMAFPRVKPAPDETSFSEALLKRNQDLAPNSAEQASILSLVTKINNVIDNLIVAPGTFEVQIEEVRQVGSYKKGTMTTGHNVADLVVILKILPTLEAVAALGNKVVESLRAQDPSEVLTMLTNETGFEISSSDATVKILITTVPPNLRKLDPELHLDIKVLQSALAAIRHARWFEENASQSTVKVLIRLLKDLRIRFPGFEPLTPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQILAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTAQTLVRILSHGGFRKILGQEGDASYLASEISTWDGVIVTPSEKAYEKPPEKKEGEEEEENTEEPPQGEEEESMETQE

Sequence Length  390

Source  Homo sapiens (Human)

UniProt ID Q12905

Gene ILF2 (NF45)

Target Organism  JEV

Activity 

• [Ref.31212927]Japanese Encephalitis Virus(JEV):ILF2 interacts with JEV NS3, and involved in the JEV life cycle and inhibits JEV replication in 293T cells.

PDB ID  None

Predicted Structure Download  AF-Q12905-F1

Modification  ①Phosphorylation of Ser at position 52,68.②The Arg at position 16,24 indicates Omega-N-methylarginine.③Phosphorylation of Thr at position 388.

C19orf66 was suggested to be a novel ISG, the products of which can suppress DENV, WNV, hepatitis C virus (HCV) and Kunjin virus, Chikungunya virus, herpes simplex virus type 1, and human adenovirus replication in vitro.

Literature 1

Title   Cellular Interleukin Enhancer-Binding Factor 2, ILF2, Inhibits Japanese Encephalitis Virus Replication In Vitro.

Pubmed ID   31212927

Author   Cui X, Qian P, Rao T, Wei Y, Zhao F, Zhang H, Chen H, Li X.