DRAVPR ID  DRAVPR0055

Name   E3 ubiquitin-protein ligase MARCHF2

Sequence  MTTGDCCHLPGSLCDCSGSPAFSKVVEATGLGPPQYVAQVTSRDGRLLSTVIRALDTPSDGPFCRICHEGANGECLLSPCGCTGTLGAVHKSCLEKWLSSSNTSYCELCHTEFAVEKRPRPLTEWLKDPGPRTEKRTLCCDMVCFLFITPLAAISGWLCLRGAQDHLRLHSQLEAVGLIALTIALFTIYVLWTLVSFRYHCQLYSEWRKTNQKVRLKIREADSPEGPQHSPLAAGLLKKVAEETPV

Sequence Length  246

Source  Homo sapiens (Human)

UniProt ID Q9P0N8

Gene MARCHF2 

Target Organism  HIV-1

Activity 

• [Ref.29573664]Human immunodeficiency virus type 1(HIV-1):MARCH2 decreased or increased the HIV-1 production in both the VSV-G- and Env-pseudo-typed HIV-1 production system. And it exerted its function by degrading VSV-G via the lysosome or by reducing the amount of Env on the plasma membrane.

PDB ID  None

Predicted Structure Download  No predicted structure information available for the entry

Modification  No modifications on the sequence.

MARCH8 might display broad-spectrum activity against enveloped viruses.

Literature 1

Title   MARCH2 is upregulated in HIV-1 infection and inhibits HIV-1 production through envelope protein translocation or degradation.

Pubmed ID   29573664

Author   Zhang Y, Lu J, Liu X.