DRAVPR ID  DRAVPR0056

Name   E3 ubiquitin-protein ligase MARCHF8

Sequence  MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASAPAPVSSFSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENKHGYGICHSDTNSSCCTEPEDTGAEIIHV

Sequence Length  291

Source  Homo sapiens (Human)

UniProt ID Q5T0T0

Gene MARCHF8

Target Organism  HIV-1

Activity 

• [Ref.26523972]Human immunodeficiency virus type 1(HIV-1):MARCH8 blocks the incorporation of HIV-1 envelope glycoprotein into virus particles by downregulating it from the cell surface, probably through their interaction, resulting in a substantial reduction in the efficiency of viral entry.

PDB ID  2D8S 

Predicted Structure Download  AF-Q5T0T0-F1

Modification  Phosphorylation of Ser at position 253.

SAMHD1 interferes with HIV infection of macrophages by preventing efficient viral cDNA synthesis.HIV-2 and related simian viruses have evolved the Vpx function to counteract SAMHD1.

Literature 1

Title   MARCH8 inhibits HIV-1 infection by reducing virion incorporation of envelope glycoproteins.

Pubmed ID   26523972

Author   Tada T, Zhang Y, Koyama T, Tobiume M, Tsunetsugu-Yokota Y, Yamaoka S, Fujita H, Tokunaga K.