DRAVPR ID  DRAVPR0058

Name   Interferon-induced GTP-binding protein Mx2

Sequence  MSKAHKPWPYRRRSQFSSRKYLKKEMNSFQQQPPPFGTVPPQMMFPPNWQGAEKDAAFLAKDFNFLTLNNQPPPGNRSQPRAMGPENNLYSQYEQKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKQPCEAWAGRISYRNTELELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDLTIIDLPGITRVAVDNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHEVDPEGDRTIGILTKPDLMDRGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEITNRLSLAEATKKEITFFQTHPYFRVLLEEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRESHQKATEELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEGEEVVRENETRLYNKIREDFKNWVGILATNTQKVKNIIHEEVEKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPALSMLQKAMEIIQQAFINVAKKHFGEFFNLNQTVQSTIEDIKVKHTAKAENMIQLQFRMEQMVFCQDQIYSVVLKKVREEIFNPLGTPSQNMKLNSHFPSNESSVSSFTEIGIHLNAYFLETSKRLANQIPFIIQYFMLRENGDSLQKAMMQILQEKNRYSWLLQEQSETATKRRILKERIYRLTQARHALCQFSSKEIH

Sequence Length  715

Source  Homo sapiens (Human)

UniProt ID P20592

Gene MX2

Target Organism  HIV-1

Activity 

• [Ref.24121441]Human immunodeficiency virus type 1(HIV-1): MX2 acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA.

PDB ID  4WHJ  4X0R  5UOT 

Predicted Structure Download  AF-P20592-F1

Modification  No modifications on the sequence.

Human MxA protein has a broad antiviral activity against a wide range of RNA and even some DNA viruses, including influenza A/B/C virus, ASFV(African swine fever virus); CCHFV(Crimean-Congo hemorrhagic fever virus); CVB(Coxsackie virus B); HBV(hepatitis B virus); HNTV(Hantaan virus); HPIV-3(human parainfluenza virus type 3); IBDV( infectious bursal disease virus); LACV(LaCrosse virus); MV(measles virus); RVFV(Rift Valley fever virus); SFV(Semliki Forest virus); THOV(Thogoto virus); VSV(vesicular stomatitis virus).

Literature 1

Title   Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection.

Pubmed ID   24048477

Author   Goujon C, Moncorgé O, Bauby H, Doyle T, Ward CC, Schaller T, Hué S, Barclay WS, Schulz R, Malim MH.

Literature 2

Title   MX2 is an interferon-induced inhibitor of HIV-1 infection.

Pubmed ID   24121441

Author   Kane M, Yadav SS, Bitzegeio J, Kutluay SB, Zang T, Wilson SJ, Schoggins JW, Rice CM, Yamashita M, Hatziioannou T, Bieniasz PD.