DRAVPR ID  DRAVPR0059

Name   Interferon-induced GTP-binding protein Mx1(MxA)

Sequence  MVVSEVDIAKADPAAASHPLLLNGDATVAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKLVNEDKWRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQLSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIKNFEEFFNLHRTAKSKIEDIRAEQEREGEKLIRLHFQMEQIVYCQDQVYRGALQKVREKELEEEKKKKSWDFGAFQSSSATDSSMEEIFQHLMAYHQEASKRISSHIPLIIQFFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERSDTSDKRKFLKERLARLTQARRRLAQFPG

Sequence Length  662

Source  Homo sapiens (Human)

UniProt ID P20591

Gene MX1

Target Organism  IAV,DUGV,VSV

Activity 

• [Ref.14687945]Dugbe nairovirus(DUGV):MX1 protein inhibits the replication of DUGV.
• [Ref.2161946]Influenza virus/vesicular stomatitis virus(VSV):transfected cell lines expressing MxA acquired a high degree of resistance to influenza A virus and vesicular stomatitis virus.

PDB ID  3LJB  3SZR  3SZR  4P4S  4P4T  4P4U  5GTM 

Predicted Structure Download  AF-P20591-F1

Modification  The N-terminal is acetylation.

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Literature 1

Title   Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity.

Pubmed ID   21166595

Author   Haller O, Kochs G.

Literature 2

Title   Inhibition of Dugbe nairovirus replication by human MxA protein.

Pubmed ID   14687945

Author   Bridgen A, Dalrymple DA, Weber F, Elliott RM.

Literature 3

Title   Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein.

Pubmed ID   2161946

Author   Pavlovic J, Zürcher T, Haller O, Staeheli P.