DRAVPR ID  DRAVPR0060

Name   Interferon-induced GTP-binding protein Mx1

Sequence  MKERTSACRHGTPQKHPDTSEESQAMESVDNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKQLKQGEKWSGKVIYKDTEIEISHPSLVEREINKAQNLIAGEGLKISSDLISLEVSSPHVPDLTLIDLPGITRVAVGDQPADIEHKIKRLITEYIQKQETINLVVVPSNVDIATTEALKMAQEVDPQGDRTIGILTKPDLVDRGTEDKVVDVVRNLVCHLKKGYMIVKCRGQQDIQEQLSLAEALQKEQVFFKEHPQFRVLLEDGKATVPCLAKRLTMELTSHICKSLPILENQINVNHQIASEELQKYGADIPEDDSKRLSFLMNKINVFNKDILSLVQAQENISWEESRLFTKLRNEFLAWNDYIEEHFKKTLGSSEKHSQMEKFESHYRGRELPGFVDYKAFENIIKKEVKALEEPALNMLHRVTTMVKNAFTKVSSNNFGDFLNLHSTAKSKIEDIRFNQEKEAEKLIRLHFQMEHIVYCQDQAYKKALQEIREKEAEKEKSTFGAFQHNSPRKELTTTEMTQHLNAYYQECGRNIGRQIPLIIQYSILQTFGQEMEKAMLQLLQDTSKCNWFLTEQSDSREKKKFLKRRLLRLDEAQRKLAKFSN

Sequence Length  652

Source  Rattus norvegicus (Rat)

UniProt ID P18588

Gene Mx1

Target Organism  IAV,THOV

Activity 

• [Ref.21166595]influenza A virus(IAV)/Thogoto virus(THOV):exhibits antiviral activity against IAV and THOV.
• [Ref.8249287]Influenza A virus(IAV):murine Mx1 protein blocks primary transcription of orthomyxoviruses via molecular interaction with the PB2 subunit of the viral polymerase.

PDB ID  None

Predicted Structure Download  AF-P18588-F1

Modification  No modifications on the sequence.

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Literature 1

Title   Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity. 

Pubmed ID   21166595

Author   Haller O, Kochs G.

Literature 2

Title   Function of the mouse Mx1 protein is inhibited by overexpression of the PB2 protein of influenza virus.

Pubmed ID   8249287

Author   Stranden AM, Staeheli P, Pavlovic J.