General Information


DRAVPR ID  DRAVPR0062

Name   Interferon-induced GTP-binding protein Mx1

Sequence 

Sequence Length  663

Source  Sus scrofa (Pig)

UniProt ID P27594

Gene MX1



Activity Information


Target Organism  IAV

Activity 

  • [Ref.20167191]Influenza A virus(IAV):Inhibits IAV replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles.



Structure Information


PDB ID  None

Predicted Structure Download  AF-P27594-F1

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Modification  No modifications on the sequence.



Comment


BoMx1 inhibits the replication of members of the Rhabdoviridae and Orthomyxoviridae families. Contrary to human MxA, however, Sendai, bovine and human parainfluenza-3, and measles viruses are resistant to boMx1.



Literature Information


Literature 1

Title   Interferon-induced Sus scrofa Mx1 blocks endocytic traffic of incoming influenza A virus particles.

Pubmed ID   20167191

Author   Palm M, Garigliany MM, Cornet F, Desmecht D.