General Information


DRAVPR ID  DRAVPR0064

Name   Interferon-induced GTP-binding protein Mx2

Sequence 

Sequence Length  655

Source  Mus musculus (Mouse)

UniProt ID Q9WVP9

Gene Mx2



Activity Information


Target Organism  VSV,HNTV

Activity 

  • [Ref.21166595]vesicular stomatitis virus(VSV)/Hantaan virus(HNTV):exhibits antiviral activity against VSV and HNTV.
  • [Ref.11266216]Hantavirus(HNTV):When the Mx2 gene was constitutively expressed in transfected Vero cells, it prvented the accumulation of viral transcripts and proteins of hantaviruses.
  • [Ref.10233954]vesicular stomatitis virus(VSV):Mx2 inhibits the replication of VAV.



Structure Information


PDB ID  None

Predicted Structure Download  AF-Q9WVP9-F1

';

Modification  No modifications on the sequence.



Comment


No comments found in the entry



Literature Information


Literature 1

Title   Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity. 

Pubmed ID   21166595

Author   Haller O, Kochs G.

Literature 2

Title   Mouse Mx2 protein inhibits hantavirus but not influenza virus replication.

Pubmed ID   11266216

Author   Jin HK, Yoshimatsu K, Takada A, Ogino M, Asano A, Arikawa J, Watanabe T.

Literature 3

Title   Identification of the murine Mx2 gene: interferon-induced expression of the Mx2 protein from the feral mouse gene confers resistance to vesicular stomatitis virus.

Pubmed ID   10233954

Author   Jin HK, Takada A, Kon Y, Haller O, Watanabe T.