To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVPR ID DRAVPR0070
Name Zinc finger CCCH-type antiviral protein 1(ZAP)
Sequence
Sequence Length 776
Source Rattus norvegicus (Rat)
UniProt ID Q8K3Y6
Gene Zc3hav1
Activity Information
Target Organism SINV,EBOV,MARV
Activity
Structure Information
PDB ID 3U9G
Predicted Structure Download AF-Q8K3Y6-F1
Modification ①Phosphorylation of Ser at position 257,262,266,270,274,283,325,351,398,544,667.②Phosphorylation of Thr at position 278.③Phosphorylation of Tyr at position 501.
Comment
The zinc-finger antiviral protein (ZAP) is a host factor that specifically inhibits the replication of certain viruses, including Moloney murine leukemia virus (MoMLV), HIV-1, and certain alphaviruses and filoviruses.
Literature Information
Literature 1
Title The zinc finger antiviral protein acts synergistically with an interferon-induced factor for maximal activity against alphaviruses.
Pubmed ID 17928353
Author MacDonald MR, Machlin ES, Albin OR, Levy DE.
Literature 2
Title Inhibition of filovirus replication by the zinc finger antiviral protein.
Pubmed ID 17182693
Author Müller S, Möller P, Bick MJ, Wurr S, Becker S, Günther S, Kümmerer BM.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.