DRAVPR ID  DRAVPR0071

Name   Zinc finger CCCH-type antiviral protein 1

Sequence  MADPEVCCFITKILCAHGGRMALDALLQEIALSEPQLCEVLQVAGPDRFVVLETGGEAGITRSVVATTRARVCRRKYCQRPCDNLHLCKLNLLGRCNYSQSERNLCKYSHEVLSEENFKVLKNHELSGLNKEELAVLLLQSDPFFMPEICKSYKGEGRQQICNQQPPCSRLHICDHFTRGNCRFPNCLRSHNLMDRKVLAIMREHGLNPDVVQNIQDICNSKHMQKNPPGPRAPSSHRRNMAYRARSKSRDRFFQGSQEFLASASASAERSCTPSPDQISHRASLEDAPVDDLTRKFTYLGSQDRARPPSGSSKATDLGGTSQAGTSQRFLENGSQEDLLHGNPGSTYLASNSTSAPNWKSLTSWTNDQGARRKTVFSPTLPAARSSLGSLQTPEAVTTRKGTGLLSSDYRIINGKSGTQDIQPGPLFNNNADGVATDITSTRSLNYKSTSSGHREISSPRIQDAGPASRDVQATGRIADDADPRVALVNDSLSDVTSTTSSRVDDHDSEEICLDHLCKGCPLNGSCSKVHFHLPYRWQMLIGKTWTDFEHMETIEKGYCNPGIHLCSVGSYTINFRVMSCDSFPIRRLSTPSSVTKPANSVFTTKWIWYWKNESGTWIQYGEEKDKRKNSNVDSSYLESLYQSCPRGVVPFQAGSRNYELSFQGMIQTNIASKTQKDVIRRPTFVPQWYVQQMKRGPDHQPAKTSSVSLTATFRPQEDFCFLSSKKYKLSEIHHLHPEYVRVSEHFKASMKNFKIEKIKKIENSELLDKFTWKKSQMKEEGKLLFYATSRAYVESICSNNFDSFLHETHENKYGKGIYFAKDAIYSHKNCPYDAKNVVMFVAQVLVGKFTEGNITYTSPPPQFDSCVDTRSNPSVFVIFQKDQVYPQYVIEYTEDKACVIS

Sequence Length  902

Source  Homo sapiens (Human)

UniProt ID Q7Z2W4

Gene ZC3HAV1

Target Organism  XMRV,HIV-1

Activity 

• [Ref.22720057]Xenotropic murine leukemia virus-related virus (XMRV):ZAP inhibits XMRV replication by preventing the accumulation of viral mRNA in the cytoplasm.
• [Ref.21876179]Human immunodeficiency virus type 1(HIV-1):ZAP inhibits HIV-1 by recruiting both the 5′ and 3′ mRNA degradation machinery to specifically promote the degradation of multiply spliced HIV-1 mRNAs.

PDB ID  2X5Y  4X52  6UEI  6UEJ  7KZH  7TGQ 

Predicted Structure Download  AF-Q7Z2W4-F1

Modification  ①Phosphorylation of Ser at position 257,263,267,271,275,284,302,327,335,355,378,387,407,469,492,494,572,590.②Phosphorylation of Thr at position 554,393.③The N-terminal is Acetylation.

human OAS3 exhibits antiviral activity against alphaviruses, such as the Chikungunya virus, the Sindbis virus, and the Semliki Forest virus,

Literature 1

Title   Zinc-finger antiviral protein inhibits XMRV infection. 

Pubmed ID   22720057

Author   Wang X, Tu F, Zhu Y, Gao G.

Literature 2

Title   Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation.

Pubmed ID   21876179

Author   Zhu Y, Chen G, Lv F, Wang X, Ji X, Xu Y, Sun J, Wu L, Zheng YT, Gao G.