DRAVPR ID  DRAVPR0072

Name   2'-5'-oligoadenylate synthase 3

Sequence  MDLYSTPAAALDRFVARRLQPRKEFVEKARRALGALAAALRERGGRLGAAAPRVLKTVKGGSSGRGTALKGGCDSELVIFLDCFKSYVDQRARRAEILSEMRASLESWWQNPVPGLRLTFPEQSVPGALQFRLTSVDLEDWMDVSLVPAFNVLGQAGSGVKPKPQVYSTLLNSGCQGGEHAACFTELRRNFVNIRPAKLKNLILLVKHWYHQVCLQGLWKETLPPVYALELLTIFAWEQGCKKDAFSLAEGLRTVLGLIQQHQHLCVFWTVNYGFEDPAVGQFLQRQLKRPRPVILDPADPTWDLGNGAAWHWDLLAQEAASCYDHPCFLRGMGDPVQSWKGPGLPRAGCSGLGHPIQLDPNQKTPENSKSLNAVYPRAGSKPPSCPAPGPTGAASIVPSVPGMALDLSQIPTKELDRFIQDHLKPSPQFQEQVKKAIDIILRCLHENCVHKASRVSKGGSFGRGTDLRDGCDVELIIFLNCFTDYKDQGPRRAEILDEMRAQLESWWQDQVPSLSLQFPEQNVPEALQFQLVSTALKSWTDVSLLPAFDAVGQLSSGTKPNPQVYSRLLTSGCQEGEHKACFAELRRNFMNIRPVKLKNLILLVKHWYRQVAAQNKGKGPAPASLPPAYALELLTIFAWEQGCRQDCFNMAQGFRTVLGLVQQHQQLCVYWTVNYSTEDPAMRMHLLGQLRKPRPLVLDPADPTWNVGHGSWELLAQEAAALGMQACFLSRDGTSVQPWDVMPALLYQTPAGDLDKFISEFLQPNRQFLAQVNKAVDTICSFLKENCFRNSPIKVIKVVKGGSSAKGTALRGRSDADLVVFLSCFSQFTEQGNKRAEIISEIRAQLEACQQERQFEVKFEVSKWENPRVLSFSLTSQTMLDQSVDFDVLPAFDALGQLVSGSRPSSQVYVDLIHSYSNAGEYSTCFTELQRDFIISRPTKLKSLIRLVKHWYQQCTKISKGRGSLPPQHGLELLTVYAWEQGGKDSQFNMAEGFRTVLELVTQYRQLCIYWTINYNAKDKTVGDFLKQQLQKPRPIILDPADPTGNLGHNARWDLLAKEAAACTSALCCMGRNGIPIQPWPVKAAV

Sequence Length  1087

Source  Homo sapiens (Human)

UniProt ID Q9Y6K5

Gene OAS3

Target Organism  DENV,CHIKV

Activity 

• [Ref.19923450]dengue virus(DENV):The antiviral effects of human OAS3 p100 correlate with their abilities to trigger RNase L activation in DEN-2-infected cells.
• [Ref.19056102]Chikungunya virus(CHIKV):OAS3 exhibits antiviral effect by blocking the early stage of virus replication.

PDB ID  4S3N 

Predicted Structure Download  AF-Q9Y6K5-F1

Modification  Phosphorylation of Thr at position 365.

OASL possesses two domains with HCV inhibitory activity. The OAS-homology domain without OAS activity is inhibitory for cell growth as well as HCV replication, whereas C-terminal Ub is inhibitory only for HCV replication.

Literature 1

Title   Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection.

Pubmed ID   19923450

Author   Lin RJ, Yu HP, Chang BL, Tang WC, Liao CL, Lin YL. 

Literature 2

Title   The large form of human 2',5'-Oligoadenylate Synthetase (OAS3) exerts antiviral effect against Chikungunya virus.

Pubmed ID   19056102

Author   Bréhin AC, Casadémont I, Frenkiel MP, Julier C, Sakuntabhai A, Desprès P.