To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVPR ID DRAVPR0076
Name 2'-5'-oligoadenylate synthase 2
Sequence
Sequence Length 742
Source Mus musculus (Mouse)
UniProt ID E9Q9A9
Gene Oas2
Activity Information
Target Organism No specific virus mentioned in the entry
Activity [Ref.12396720]2',5'-Oligoadenylate synthetase (2-5OAS) is one of the interferon (IFN)-induced proteins and mediates the antiviral action of IFN.##[Ref.21142819]The 2'-5' oligoadenylate synthetases (OAS) are interferon-induced antiviral enzymes that recognize virally produced dsRNA and initiate RNA destabilization through activation of RNase L within infected cells.
Structure Information
PDB ID None
Predicted Structure Download AF-E9Q9A9-F1
Modification ①The Gly at position 2 indicates N-myristoyl glycine.②Acetylation of Lys at position 417.
Comment
No comments found in the entry
Literature Information
Literature 1
Title Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family.
Pubmed ID 12396720
Author Kakuta S, Shibata S, Iwakura Y.
Literature 2
Title The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities.
Pubmed ID 21142819
Author Kristiansen H, Gad HH, Eskildsen-Larsen S, Despres P, Hartmann R.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.