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General Information
DRAVPR ID DRAVPR0080
Name NF-kappa-B essential modulator(NEMO)
Sequence
Sequence Length 419
Source Homo sapiens (Human)
UniProt ID Q9Y6K9
Gene IKBKG
Activity Information
Target Organism No specific virus mentioned in the entry
Activity [Ref.20724660]TRIM23-mediated ubiquitin conjugation to NEMO is essential for TLR3- and RIG-I/MDA5-mediated antiviral innate and inflammatory responses.
Structure Information
Predicted Structure Download AF-Q9Y6K9-F1
Modification Phosphorylation of Ser at position 31,43,68,85,376,387.
Comment
Antiviral activity depends on K27-linked polyubiquitin conjugation to multiple sites of NEMO by TRIM23 expression.
Literature Information
Literature 1
Title Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense.
Pubmed ID 20724660
Author Arimoto K, Funami K, Saeki Y, Tanaka K, Okawa K, Takeuchi O, Akira S, Murakami Y, Shimotohno K.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.