To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVPR ID DRAVPR0084
Name Nuclear factor erythroid 2-related factor 2(HEBP1,Nrf-2)
Sequence
Sequence Length 605
Source Homo sapiens (Human)
UniProt ID Q16236
Gene NFE2L2(NRF2)
Activity Information
Target Organism SARS-CoV-2
Activity
Structure Information
PDB ID 2FLU 2LZ1 4IFL 5WFV 7K2A 7K2E 7O7B
Predicted Structure Download AF-Q16236-F1
Modification ①Phosphorylation of Ser at position 40,215.②Glycosylation of Lys at position 462,472,487,574.③Glycosylation of Arg at position 499,569.④The Lys at position 596 and 599 indicates N6-acetyllysine.
Comment
The inhibitory effect extends to the replication of several other pathogenic viruses including Herpes Simplex Virus-1 and-2, Vaccinia virus, and Zika virus through a type I interferon (IFN)-independent mechanism.
Literature Information
Literature 1
Title SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate.
Pubmed ID 33009401
Author Olagnier D, Farahani E, Thyrsted J, Blay-Cadanet J, Herengt A, Idorn M, Hait A, Hernaez B, Knudsen A, Iversen MB, Schilling M, Jørgensen SE, Thomsen M, Reinert LS, Lappe M, Hoang HD, Gilchrist VH, Hansen AL, Ottosen R, Nielsen CG, Møller C, van der Horst D, Peri S, Balachandran S, Huang J, Jakobsen M, Svenningsen EB, Poulsen TB, Bartsch L, Thielke AL, Luo Y, Alain T, Rehwinkel J, Alcamí A, Hiscott J, Mogensen TH, Paludan SR, Holm CK.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.