General Information


DRAVPR ID  DRAVPR0085

Name   Interferon alpha-4

Sequence 

Sequence Length  189

Source  Homo sapiens (Human)

UniProt ID P05014

Gene IFNA4



Activity Information


Target Organism  No specific virus mentioned in the entry

Activity  [Ref.9334213]IFN-alpha have antiviral activities.



Structure Information


PDB ID  None

Predicted Structure Download  AF-P05014-F1

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Modification  There are two disulfide bonds between Cys24 and Cys122, Cys52 and Cys162.



Comment


No comments found in the entry



Literature Information


Literature 1

Title   A region of the beta subunit of the interferon alpha receptor different from box 1 interacts with Jak1 and is sufficient to activate the Jak-Stat pathway and induce an antiviral state.

Pubmed ID   9334213

Author   Domanski P, Fish E, Nadeau OW, Witte M, Platanias LC, Yan H, Krolewski J, Pitha P, Colamonici OR.