DRAVPR ID  DRAVPR0088

Name   Mitochondrial import receptor subunit TOM70

Sequence  MAASKPVEAAVVAAAVPSSGSGVGGGGTAGPGTGGLPRWQLALAVGAPLLLGAGAIYLWSRQQRRREARGRGDASGLKRNSERKTPEGRASPAPGSGHPEGPGAHLDMNSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEIDAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAHAQTEVAKKYGLKPPTL

Sequence Length  608

Source  Homo sapiens (Human)

UniProt ID O94826

Gene TOMM70

Target Organism  SeV

Activity 

• [Ref.20628368]Tom70 is found to interact specifically with MAVS during RNA virus infection and plays an essential role in the antiviral response.
• [Ref.25609812]Sendai virus:Tom70 recruits IRF3/Bax complex to the mitochondrial outer membrane through Hsp90, which thus induces the release of cytochrome c into the cytosol, initiating virus-induced apoptosis.

PDB ID  7DHG  7KDT 

Predicted Structure Download  AF-O94826-F1

Modification  ①Phosphorylation of Ser at position 91,96,434.②The N-terminal is acetylation.③The Arg at position 71 indicates Omega-N-methylarginine.④The Lys at position 185 indicates N6-acetyllysine.

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Literature 1

Title   Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.

Pubmed ID   20628368

Author   Liu XY, Wei B, Shi HX, Shan YF, Wang C. 

Literature 2

Title   Tom70 mediates Sendai virus-induced apoptosis on mitochondria.

Pubmed ID   25609812

Author   Wei B, Cui Y, Huang Y, Liu H, Li L, Li M, Ruan KC, Zhou Q, Wang C.