DRAVPR ID  DRAVPR0091

Name   Autophagy-related protein 16-1

Sequence  MSSGLRAADFPRWKRHIAEELRRRDRLQRQAFEEIILQYTKLLEKSDLHSVLTQKLQAEKHDMPNRHEISPGHDGAWNDSQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLNNQMQQKDKEIQMNEAKISEYLQTISDLETNCLDLRTKLQDLEVANQTLKDEYDALQITFTALEEKLRKTTEENQELVTRWMAEKAQEANRLNAENEKDSRRRQARLQKELAEAAKEPLPVEQDDDIEVIVDETSDHTEETSPVRAVSRAATKRLSQPAGGLLDSITNIFGRRSVSSIPVPQDIMDTHPASGKDVRVPTTASYVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEAFGDKCEFKGSLSGSNAGITSIEFDSAGAYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRSESVVREMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAVKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYVWSVLTGKVEKVLSKQHSSSINAVAWAPSGLHVVSVDKGSRAVLWAQP

Sequence Length  607

Source  Mus musculus (Mouse)

UniProt ID Q8C0J2

Gene Atg16l1

Target Organism  IAV

Activity 

• [Ref.33586810]Influenza A virus(IAV):Non‐canonical autophagy limits IAV infection independently of phagocytic cells.

PDB ID  6SUR  6Y09  6ZAY 

Predicted Structure Download  AF-Q8C0J2-F1

Modification  Phosphorylation of Ser at position 139,269,287.

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Literature 1

Title   Non-canonical autophagy functions of ATG16L1 in epithelial cells limit lethal infection by influenza A virus.

Pubmed ID   33586810

Author   Wang Y, Sharma P, Jefferson M, Zhang W, Bone B, Kipar A, Bitto D, Coombes JL, Pearson T, Man A, Zhekova A, Bao Y, Tripp RA, Carding SR, Yamauchi Y, Mayer U, Powell PP, Stewart JP, Wileman T.