DRAVPR ID  DRAVPR0093

Name   Interferon-induced protein with tetratricopeptide repeats 1

Sequence  MGENADGDQVMENLLQLRCHFTWKLLFENNDIPDLEVRISEQVQFLDIKNPLGMHNLLAYVRHLKGQQDEALQSLKEAEALIQSEQLSKRSLATWGNCAWLHYHRGSLAEAQIYLDKVEKVCKEFSSPFRYRLECAEMDCEEGWALLKCGGGNYKQAMACFAKALKVEPENPEYNTGYAVVAYRQDLDDNFISLEPLRKAVRLNPEDPYLKVLLALKLQDLGEHVEAEAHIEEALSSTSCQSYVIRYAAKYFRRKHRVDKALHLLNRALQASPSSGYLHYQKGLCYKQQISQLRTSRNRQPRRQDNVQELAQQAIHEFQETLKLRPTFEMAYVCMAEVQAEIHQYEEAERNFQKALNNKTLVAHIEQDIHLRYGRFLQFHKQSEDKAITLYLKGLKVEEKSFAWRKLLTALEKVAERRVCQNVHLVESTSLLGLVYKLKGQEKNALFYYEKALRLTGEMNPAF

Sequence Length  463

Source  Mus musculus (Mouse)

UniProt ID Q64282

Gene Ifit1

Target Organism  WNV

Activity 

• [Ref.22589727]West Nile virus(WNV):Ifit1 restricts replication of WNV lacking 2′-O methylation in subsets of primary cells.

PDB ID  None

Predicted Structure Download  AF-Q64282-F1

Modification  No modifications on the sequence.

Ifit1 reportedly have antiviral activity against several viruses including human papilloma, Sindbis, vesicular stomatitis, and hepatitis C viruses.

Literature 1

Title   2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo. 

Pubmed ID   22589727

Author   Szretter KJ, Daniels BP, Cho H, Gainey MD, Yokoyama WM, Gale M Jr, Virgin HW, Klein RS, Sen GC, Diamond MS.