DRAVPR ID  DRAVPR0094

Name   Interferon-induced protein with tetratricopeptide repeats 1(P56)

Sequence  MSTNGDDHQVKDSLEQLRCHFTWELSIDDDEMPDLENRVLDQIEFLDTKYSVGIHNLLAYVKHLKGQNEEALKSLKEAENLMQEEHDNQANVRSLVTWGNFAWMYYHMGRLAEAQTYLDKVENICKKLSNPFRYRMECPEIDCEEGWALLKCGGKNYERAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLATKNHKPFSLLPLRQAVRLNPDNGYIKVLLALKLQDEGQEAEGEKYIEEALANMSSQTYVFRYAAKFYRRKGSVDKALELLKKALQETPTSVLLHHQIGLCYKAQMIQIKEATKGQPRGQNREKLDKMIRSAIFHFESAVEKKPTFEVAHLDLARMYIEAGNHRKAEENFQKLLCMKPVVEETMQDIHFHYGRFQEFQKKSDVNAIIHYLKAIKIEQASLTRDKSINSLKKLVLRKLRRKALDLESLSLLGFVYKLEGNMNEALEYYERALRLAADFENSVRQGP

Sequence Length  478

Source  Homo sapiens (Human)

UniProt ID P09914

Gene IFIT1

Target Organism  HPV,HCV

Activity 

• [Ref.19008854]human papillomaviruses(HPV):P56 inhibits the DNA helicase activity of E1 and E1-mediated HPV DNA replication.
• [Ref.21976647]Hepatitis C virus(HCV):IFITM1 inhibits HCV replication in IHH or Huh7 cells

PDB ID  4HOU  5UDI  6C6K 

Predicted Structure Download  AF-P09914-F1

Modification  No modifications on the sequence.

Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.

Literature 1

Title   Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1.

Pubmed ID   19008854

Author   Terenzi F, Saikia P, Sen GC.

Literature 2

Title   ISG56 and IFITM1 proteins inhibit hepatitis C virus replication.

Pubmed ID   21976647

Author   Raychoudhuri A, Shrivastava S, Steele R, Kim H, Ray R, Ray RB.