DRAVPR ID  DRAVPR0095

Name   Ubiquitin-like protein ISG15

Sequence  MAWDLKVKMLGGNDFLVSVTNSMTVSELKKQIAQKIGVPAFQQRLAHQTAVLQDGLTLSSLGLGPSSTVMLVVQNCSEPLSILVRNERGHSNIYEVFLTQTVDTLKKKVSQREQVHEDQFWLSFEGRPMEDKELLGEYGLKPQCTVIKHLRLRGGGGDQCA

Sequence Length  161

Source  Mus musculus (Mouse)

UniProt ID Q64339

Gene Isg15

Target Organism  SBV,HSV-1

Activity 

• [Ref.17227866]Sindbs virus(SBV)/herpes virus type 1 (HSV-1):ISG15 inhibits the infection of SBV and HSV-1.

PDB ID  5CHF  5TL7  6YVA 

Predicted Structure Download  AF-Q64339-F1

Modification  The Cys at position 144 and 155 indicates S-nitrosocysteine.

ISG15 expression has been shown to inhibit the release of HIV-1 virions in vitro.

Literature 1

Title   Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo.

Pubmed ID   16254333

Author   Lenschow DJ, Giannakopoulos NV, Gunn LJ, Johnston C, O'Guin AK, Schmidt RE, Levine B, Virgin HW 4th.

Literature 2

Title   IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses.

Pubmed ID   17227866

Author   Lenschow DJ, Lai C, Frias-Staheli N, Giannakopoulos NV, Lutz A, Wolff T, Osiak A, Levine B, Schmidt RE, García-Sastre A, Leib DA, Pekosz A, Knobeloch KP, Horak I, Virgin HW 4th.