DRAVPR ID  DRAVPR0096

Name   S-phase kinase-associated protein 2

Sequence  MHRKHLQEIPDLSSNVATSFTWGWDSSKTSELLSGMGVSALEKEEPDSENIPQELLSNLGHPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSPFRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIPTLKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQKPSCL

Sequence Length  424

Source  Homo sapiens (Human)

UniProt ID Q13309

Gene SKP2

Target Organism  HCV

Activity 

• [Ref.27194766]Hepatitis C virus (HCV):SKP2 has an antiviral activity towards HCV through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A.

PDB ID  1FQV  1FS2  2AST  7B5R 

Predicted Structure Download  AF-Q13309-F1

Modification  ①Phosphorylation of Ser at position 64,72,75,179.②The Lys at position 68 and 71 indicates N6-acetyllysine.

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Literature 1

Title    ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation Pathway.

Pubmed ID   27194766

Author   Xue B, Yang D, Wang J, Xu Y, Wang X, Qin Y, Tian R, Chen S, Xie Q, Liu N, Zhu H.