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General Information
DRAVPR ID DRAVPR0097
Name Serine incorporator 3
Sequence
Sequence Length 473
Source Homo sapiens (Human)
UniProt ID Q13530
Gene SERINC3
Activity Information
Target Organism HIV-1
Activity
Structure Information
PDB ID None
Predicted Structure Download AF-Q13530-F1
Modification ①Phosphorylation of Ser at position 371.②Glycosylation of Asn at position 34.
Comment
HIV-1 Nef and MLV glycoGag efficiently down-regulate SERINC3 form the cell surface, which prevents their incorporation into HIV-1 virions and consequently counteracts their inhibitory effect on HIV-1 infectivity.
Literature Information
Literature 1
Title SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef.
Pubmed ID 26416733
Author Usami Y, Wu Y, Göttlinger HG.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.