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General Information
DRAVPR ID DRAVPR0102
Name E3 ubiquitin/ISG15 ligase TRIM25
Sequence
Sequence Length 630
Source Homo sapiens (Human)
UniProt ID Q14258
Gene TRIM25
Activity Information
Target Organism No specific virus mentioned in the entry
Activity [Ref.18248090]TRIM25 inhibits viral release.
Structure Information
Predicted Structure Download AF-Q14258-F1
Modification ①The Lys at position 273 and 567 indicates N6-acetyllysine.②Phosphorylation of Tyr at position 278.③Phosphorylation of Thr at position 91.④Phosphorylation of Ser at position 100.
Comment
TRIM25 acts as a K63 specific ubiquitin E3 ligase activating RIG-I and regulate innate immunity to viral infection.
Literature Information
Literature 1
Title TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.
Pubmed ID 18248090
Author Uchil PD, Quinlan BD, Chan WT, Luna JM, Mothes W.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.