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General Information
DRAVPR ID DRAVPR0105
Name Protein PML
Sequence
Sequence Length 882
Source Homo sapiens (Human)
UniProt ID P29590
Gene PML(TRIM19)
Activity Information
Target Organism No specific virus mentioned in the entry
Activity [Ref.18248090]The list of viruses inhibited by TRIM19 includes vesicular stomatitis virus, influenza A virus, human cytomegalovirus, herpes simplex type 1, Ebola virus, Lassa fever virus, lymphocytic choriomeningitis virus, human foamy virus and HIV.
Structure Information
PDB ID 1BOR 2MVW 4WJO 5YUF 6UYP
Predicted Structure Download AF-P29590-F1
Modification ①The Lys at posistion 487,515 indicates N6-acetyllysine.②Phosphorylation of Ser at position 8,36,38,48,117,403,493,504,505,512,518,527,530,565.③Phosphorylation of Thr at position 867.
Comment
Exhibits antiviral activity against both DNA and RNA viruses.
Literature Information
Literature 1
Title TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.
Pubmed ID 18248090
Author Uchil PD, Quinlan BD, Chan WT, Luna JM, Mothes W.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.